Rams vs. 49ers
NFL Week 10, 2025 season. Sunday, Nov 9, 2025, 3:25 PM CT. Levi's Stadium. Referee: Land Clark.
The Sim's pick: Los Angeles Rams
Sim right
55% Rams
49ers 45%
- Projected score
- LA 23, SF 21
- Sim line
- LA -1.5
- Backtest
- made after kickoff
Beat the Sim: your pick
Picks for this game locked at kickoff. See the standings.
The Sim's take
The Sim made the Rams a slight favorite on the road: 55% to beat the 49ers, with a projected score of 23-21 (LA by 1.5).
The Rams came in 6-2. The 49ers came in 6-3.
Final: Rams 42, 49ers 26. The Sim's pick was right.
Rams: last 5 games
49ers: last 5 games
- W 34-24 at Giants Week 9
- L 15-26 at Texans Week 8
- W 20-10 vs Falcons Week 7
- L 19-30 at Buccaneers Week 6
- W 26-23 at Rams Week 5
Last meetings: Rams vs. 49ers
- 2025, Week 5 SF 26 at LA 23 (OT) 49ers won
- 2024, Week 15 LA 12 at SF 6 Rams won
- 2024, Week 3 SF 24 at LA 27 Rams won
- 2023, Week 18 LA 21 at SF 20 Rams won
- 2023, Week 2 SF 30 at LA 23 49ers won
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More Week 10 games
All Week 10 picks- Raiders vs. Broncos recap
- Falcons vs. Colts recap
- Saints vs. Panthers recap
- Giants vs. Bears recap
- Jaguars vs. Texans recap
- Bills vs. Dolphins recap
- Ravens vs. Vikings recap
- Browns vs. Jets recap
- Patriots vs. Buccaneers recap
- Cardinals vs. Seahawks recap
- Lions vs. Commanders recap
- Steelers vs. Chargers recap
- Eagles vs. Packers recap
Schedule and scores: nflverse. Picks: the Sim, Hizzle's own model. Power rankings: Buck Kincaid. Times are Central. Not affiliated with the NFL.