Jaguars vs. 49ers
NFL Week 4, 2025 season. Sunday, Sep 28, 2025, 3:05 PM CT. Levi's Stadium. Referee: Clete Blakeman.
The Sim's pick: San Francisco 49ers
Sim wrong
34% Jaguars
49ers 66%
- Projected score
- JAX 19, SF 24
- Sim line
- SF -4.5
- Backtest
- made after kickoff
Beat the Sim: your pick
Picks for this game locked at kickoff. See the standings.
The Sim's take
The Sim made the 49ers a clear favorite at home: 66% to beat the Jaguars, with a projected score of 24-19 (SF by 4.5).
The Jaguars came in 2-1. The 49ers came in 3-0.
Final: Jaguars 26, 49ers 21. The Sim's pick was wrong, an upset by its numbers.
Jaguars: last 5 games
49ers: last 5 games
Last meetings: Jaguars vs. 49ers
- 2023, Week 10 SF 34 at JAX 3 49ers won
- 2021, Week 11 SF 30 at JAX 10 49ers won
- 2017, Week 16 JAX 33 at SF 44 49ers won
- 2013, Week 8 SF 42 at JAX 10 49ers won
- 2009, Week 12 JAX 3 at SF 20 49ers won
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More Week 4 games
All Week 4 picks- Seahawks vs. Cardinals recap
- Vikings vs. Steelers recap
- Commanders vs. Falcons recap
- Saints vs. Bills recap
- Browns vs. Lions recap
- Titans vs. Texans recap
- Panthers vs. Patriots recap
- Chargers vs. Giants recap
- Eagles vs. Buccaneers recap
- Colts vs. Rams recap
- Ravens vs. Chiefs recap
- Bears vs. Raiders recap
- Packers vs. Cowboys recap
- Jets vs. Dolphins recap
- Bengals vs. Broncos recap
Schedule and scores: nflverse. Picks: the Sim, Hizzle's own model. Power rankings: Buck Kincaid. Times are Central. Not affiliated with the NFL.