Cardinals vs. Colts
NFL Week 6, 2025 season. Sunday, Oct 12, 2025, 12:00 PM CT. Lucas Oil Stadium. Referee: Shawn Hochuli.
The Sim's pick: Indianapolis Colts
Sim right
33% Cardinals
Colts 67%
- Projected score
- ARI 21, IND 25
- Sim line
- IND -5
- Backtest
- made after kickoff
Beat the Sim: your pick
Picks for this game locked at kickoff. See the standings.
The Sim's take
The Sim made the Colts a clear favorite at home: 67% to beat the Cardinals, with a projected score of 25-21 (IND by 5).
The Cardinals came in 2-3. The Colts came in 4-1.
Final: Cardinals 27, Colts 31. The Sim's pick was right.
Cardinals: last 5 games
Colts: last 5 games
Last meetings: Cardinals vs. Colts
- 2021, Week 16 IND 22 at ARI 16 Colts won
- 2017, Week 2 ARI 16 at IND 13 (OT) Cardinals won
- 2013, Week 12 IND 11 at ARI 40 Cardinals won
- 2009, Week 3 IND 31 at ARI 10 Colts won
- 2005, Week 17 ARI 13 at IND 17 Colts won
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More Week 6 games
All Week 6 picks- Eagles vs. Giants recap
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- Rams vs. Ravens recap
- Cowboys vs. Panthers recap
- Seahawks vs. Jaguars recap
- Chargers vs. Dolphins recap
- Patriots vs. Saints recap
- Browns vs. Steelers recap
- Titans vs. Raiders recap
- Bengals vs. Packers recap
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- Lions vs. Chiefs recap
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- Bears vs. Commanders recap
Schedule and scores: nflverse. Picks: the Sim, Hizzle's own model. Power rankings: Buck Kincaid. Times are Central. Not affiliated with the NFL.