49ers vs. Cardinals
NFL Week 11, 2025 season. Sunday, Nov 16, 2025, 3:05 PM CT. State Farm Stadium. Referee: Carl Cheffers.
The Sim's pick: San Francisco 49ers
Sim right
59% 49ers
Cardinals 41%
- Projected score
- SF 25, ARI 22
- Sim line
- SF -2.5
- Backtest
- made after kickoff
Beat the Sim: your pick
Picks for this game locked at kickoff. See the standings.
The Sim's take
The Sim made the 49ers a slight favorite on the road: 59% to beat the Cardinals, with a projected score of 25-22 (SF by 2.5).
The 49ers came in 6-4. The Cardinals came in 3-6.
Final: 49ers 41, Cardinals 22. The Sim's pick was right.
49ers: last 5 games
- L 26-42 vs Rams Week 10
- W 34-24 at Giants Week 9
- L 15-26 at Texans Week 8
- W 20-10 vs Falcons Week 7
- L 19-30 at Buccaneers Week 6
Cardinals: last 5 games
Last meetings: 49ers vs. Cardinals
- 2025, Week 3 ARI 15 at SF 16 49ers won
- 2024, Week 18 SF 24 at ARI 47 Cardinals won
- 2024, Week 5 ARI 24 at SF 23 Cardinals won
- 2023, Week 15 SF 45 at ARI 29 49ers won
- 2023, Week 4 ARI 16 at SF 35 49ers won
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More Week 11 games
All Week 11 picks- Jets vs. Patriots recap
- Commanders vs. Dolphins recap
- Panthers vs. Falcons recap
- Buccaneers vs. Bills recap
- Chargers vs. Jaguars recap
- Bears vs. Vikings recap
- Packers vs. Giants recap
- Bengals vs. Steelers recap
- Texans vs. Titans recap
- Seahawks vs. Rams recap
- Ravens vs. Browns recap
- Chiefs vs. Broncos recap
- Lions vs. Eagles recap
- Cowboys vs. Raiders recap
Schedule and scores: nflverse. Picks: the Sim, Hizzle's own model. Power rankings: Buck Kincaid. Times are Central. Not affiliated with the NFL.