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Panthers vs. 49ers

NFL Week 12, 2025 season. Monday, Nov 24, 2025, 7:15 PM CT. Levi's Stadium. Referee: Alex Kemp.

Panthers
6-5 going in
Final
9-20
49ers
7-4 going in

The Sim's pick: San Francisco 49ers

Sim right
26% Panthers 49ers 74%
Projected score
CAR 20, SF 27
Sim line
SF -7
Backtest
made after kickoff

Beat the Sim: your pick

Picks for this game locked at kickoff. See the standings.

The Sim's take

The Sim made the 49ers a clear favorite at home: 74% to beat the Panthers, with a projected score of 27-20 (SF by 7).

The Panthers came in 6-5. The 49ers came in 7-4.

Final: Panthers 9, 49ers 20. The Sim's pick was right.

Panthers: last 5 games

49ers: last 5 games

Last meetings: Panthers vs. 49ers

  • 2022, Week 5 SF 37 at CAR 15 49ers won
  • 2019, Week 8 CAR 13 at SF 51 49ers won
  • 2017, Week 1 CAR 23 at SF 3 Panthers won
  • 2016, Week 2 SF 27 at CAR 46 Panthers won
  • 2013, Divisional Round SF 23 at CAR 10 49ers won

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Schedule and scores: nflverse. Picks: the Sim, Hizzle's own model. Power rankings: Buck Kincaid. Times are Central. Not affiliated with the NFL.