49ers vs. Colts
NFL Week 16, 2025 season. Monday, Dec 22, 2025, 7:15 PM CT. Lucas Oil Stadium. Referee: Ron Torbert.
The Sim's pick: San Francisco 49ers
Sim right
57% 49ers
Colts 43%
- Projected score
- SF 25, IND 23
- Sim line
- SF -2
- Backtest
- made after kickoff
Beat the Sim: your pick
Picks for this game locked at kickoff. See the standings.
The Sim's take
The Sim made the 49ers a slight favorite on the road: 57% to beat the Colts, with a projected score of 25-23 (SF by 2).
The 49ers came in 10-4. The Colts came in 8-6.
Final: 49ers 48, Colts 27. The Sim's pick was right.
49ers: last 5 games
Colts: last 5 games
Last meetings: 49ers vs. Colts
- 2021, Week 7 IND 30 at SF 18 Colts won
- 2017, Week 5 SF 23 at IND 26 (OT) Colts won
- 2013, Week 3 IND 27 at SF 7 Colts won
- 2009, Week 8 SF 14 at IND 18 Colts won
- 2005, Week 5 IND 28 at SF 3 Colts won
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Schedule and scores: nflverse. Picks: the Sim, Hizzle's own model. Power rankings: Buck Kincaid. Times are Central. Not affiliated with the NFL.