Slay the Spire 2 what to do first
Slay the Spire 2 what to do first: learn one character, inspect the map and prepare for the next fight. Use this opening checklist.
Start here · what to do first, Main 0.107.1
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By Hizzle Guides · Published 2026-11-05 · Facts checked 2026-11-05 · Game version checked: Main 0.107.1; Beta 0.111.0 reviewed separately. Checked November 5, 2026. No in-game testing.
Slay the Spire 2 what to do first: begin an ordinary run with Ironclad, inspect the starting reward and choose an opening route with a recovery option. Hizzle recommends making a small number of deliberate choices before copying a finished deck list.
The opening checklist
- Check your branch and version so card advice matches the run.
- Read the starting relic or Ancient offer, including any immediate payment or lasting downside.
- Look ahead to the nearest difficult fight, shop and rest site. Pick a route you can change if the first rewards are weak.
- Use early card rewards to improve damage and defense you can deploy now.
- Inspect your potions before entering the difficult fight. A potion that prevents a failed run has done its job.
What to leave for later
Do not judge the run only by whether a famous rare card appeared. A reward that needs several absent pieces can consume draws without helping your current fights. Start tracking a build direction when the deck has a way to make and use its resource.
Equally, do not erase every starter attack merely because a tier list ranks it poorly. If the replacements have not arrived, removing damage can make an elite take longer and cost more health.
A useful first-session finish
After the run ends, inspect the character screen and Timeline. The published unlock chain advances by ending runs with the required character; it does not demand an Act 3 victory for each new class. Keep the learning run and the account unlock as separate goals.
The sequence above is Hizzle’s editorial checklist. It gives a structure for learning, not a fixed number of elites, floors or minutes required to win.
Related: Slay the Spire 2 beginner guide: first run, Slay the Spire 2 Ironclad build: early plan, Slay the Spire 2 achievements: current status, Slay the Spire 2 patch notes: Main versus Beta, Slay the Spire 2 when to skip cards, Slay the Spire 2 card removal: cost and priorities.
Sources we checked
- Opening priorities and map contextChecked 2026-11-05
- Published unlock sequenceChecked 2026-11-05
- Current branch and Main changesChecked 2026-11-05
UNSURE marks what this guide hasn't established. Hizzle Guides research from public sources; we don't claim in-game testing unless a page says so.